Iris changes (atrophy, corectopia, polycoria, ectropion uvea) Contraction of corneal endothelial cells that have advanced on to the iris can result in these degenerative changes.

Patients with good visual potential may develop visual distortion and glare from these iris changes.

Iris atrophy is a very rare, progressive disorder of the eye characterized by a pupil that is out of place and/or distorted areas of degeneration on the iris (atrophy), and/or holes in the iris. This disorder most frequently affects only one eye (unilateral) and develops slowly over time. Attachment of portions of the iris to the cornea (peripheral anterior synechiae) and subsequent closure of the drainage angle may lead to secondary glaucoma and vision loss.